The White House Office of Management and Budget released Delivering Government Solutions in the 21st Century, a plan for reorganizing federal agencies. On topics related to innovation, the wide-ranging plan would make changes to education, workforce, economic development, small business and more. Some of the suggestions could advance with administrative actions only, while many will require congressional support.

Approximately 30.2 percent of NIH-funded research studies produce false positive results that make those studies not replicable by other researchers, according to a recent study from researchers at Queensland University of Technology (AU). The authors of the study contend that the reproducibility crisis is driven by “publish or perish” incentives to increase the quantity of their papers at the cost of quality.

With a focus on improving health, driving economic growth, and expanding the country’s research capacity, the National Institutes of Health (NIH) within the U.S. Department of Health and Human Services is the largest public funder of biomedical research in the world. Because of NIH’s central role in supporting science, technology, and innovation, a better understanding of the agency’s footprint may be helpful to the technology-based economic development practitioner community.

As the global economy continues to struggle through the COVID-19 pandemic, the National Institutes of Health (NIH) has released an interactive online tool for discovering success stories of small business innovation and entrepreneurship. Showcasing several of the businesses that have successfully leveraged NIH small business funding — totaling more than $1 billion annually — to develop healthcare products and services, NIH’s Small Business Education and Entrepreneurial Development (SEED) office hopes that the tool will inspire others to start businesses and develop their technologies.

Home to the Research Triangle Park and top-tier research universities like Duke University and the University of North Carolina at Chapel Hill, the Durham-Chapel Hill metropolitan area led all regions in per capita NIH funding in FY 2018 and placed sixth in total funding that year, according to a new analysis by SSTI. This edition of Useful Stats looks at all NIH awards at the regional level over the five-year period between FY 2014 and FY 2018.

In recent weeks, three separate reviews of R&D grants and awards at NIH have shed new light on issues of minority and women representation among researchers and on potential conflicts of interest by investigators. NIH has been publicly working to address concerns about representation and trustworthiness among its investigators. While the results from these studies show that the agency has more work to do, the availability of this information speaks favorably to NIH's transparent approach to these conversations. 

In this week’s edition of Useful Stats, we take a look at NIH’s SBIR/STTR program by state, including the success rate of applications, the share SBIR awards make up of NIH funding to for-profit companies by state, and the total number of awards by state. It should be noted that SSTI was able to prepare this information because of the excellent transparency of information that NIH offers on its website, a model that should be replicated by other federal agencies.

The most recently-passed federal legislation to address COVID-19 included funding for the National Institutes of Health (NIH) and the Biomedical Advanced Research and Development Authority (BARDA) to accelerate testing. The provision, added by Sens.

For the first time and in response to the COVID-19 outbreak, the National Institute of Allergy and Infectious Diseases (NIAID) together with the National Institute of General Medical Sciences (NIGMS) has activated the NIH Urgent Award mechanism. The targeted opportunity is intended to provide funds for NIH grantees applying to expand the scope of their active grant.

As the largest public funder of biomedical research in the world, NIH awards are of particular importance to the technology-based economic development community. Including new data for FY 2017 and FY 2018, this edition of Useful Stats serves as an update to an August 2017 article highlighting NIH awards by state over the past decade. In FY 2018, NIH awarded a total of $28.3 billion in funds to the 50 states and territories.

The NIH’s High-Risk, High-Reward Research program (HRHR) has the potential to overturn fundamental paradigms, but historically the applicant and awardee pools have not fully represented the demographic and geographic diversity across the U.S. biomedical workforce, says the NIH’s deputy director for extramural research.

Are you looking to increase the success rate of your state’s SBIR/STTR proposals? If so, a reminder that applications for the Small Business Administration’s Federal and State Technology (FAST) Partnership Program are due next Friday, June 28, at 4 p.m. EDT. This program provides one-year funding to organizations executing programs related to SBIR/STTR outreach, technical assistance, or financial support.

The National Science and Technology Council (NSTC) has released a new request for information (RFI) related to a national strategic plan for advanced manufacturing, and the National Institutes of Health (NIH) are seeking information on how the scientific community uses public data tools. Both RFIs provide an opportunity for the tech-based economic development field to shape the future of federal innovation policy. 

The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs of the National Institutes of Health (NIH) supported the development of 99 drugs from 1996-2020 — a total that includes 16 percent of all such treatments that made a “significant” advance over available medicines.

Despite increasing demand for life sciences research funding and larger budgets from Congress, access to the investigator research funding from the National Institutes of Health (NIH) is getting harder, according to data released May 31 by Michael Lauer, NIH deputy director for Extramural Research.  R01 grants, the oldest and predominant funding mechanism NIH uses to distribute project-specific research grants, are becoming larger in size and more exclusive in who receives the grants.

Eligible small businesses who have not previously won an SBIR/STTR award from the NIH are able to apply for help through a pilot initiative, the Applicant Assistance Program (AAP).

NIH has taken an expanded approach in defining scientists from disadvantaged backgrounds, in an effort to encourage and enable more biomedical scientists. NIH determined that the criteria they were using in defining disadvantaged was too narrow; for example, what was considered low-income ($25,750 for a family of four) is actually considered severe poverty and represents an overly strict threshold, the reviewers found.

House Committee on Energy and Commerce Chair Cathy McMorris Rodgers recently published Reforming the National Institutes of Health: Framework for Discussion. The blueprint calls for reducing the number of NIH institutes and centers (ICs) from 27 to 15, largely by merging some of them. The reorganization and proposed funding levels are illustrated in Figure 1.

In a recent study titled Does NIH select the right healthcare ventures through the SBIR grant program?, researchers from Rutgers University and the University of Connecticut took advantage of the 2009 American Recovery and Reinvestment Act (ARRA) to conduct a natural experiment.

Last month, NIH came out with a policy statement that prohibits using generative AI to analyze or critique NIH grant applications and contract proposals.

In fiscal year 2021, the nationwide success rate of applicants for National Institutes of Health (NIH) Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Phase I awards decreased slightly from FY 2020. This continued a downward trend over recent years. The success rate for NIH SBIR/STTR Phase I was nearly 13 percent (647 of 5,132 approved) in FY 2021, a decrease from nearly 14 percent (636 of 4,684 approved) in FY 2020 and from nearly 16 percent for all proposals submitted over the past decade.

Accelerators, incubators and entrepreneurial assistance programs work to ensure their startups understand their product’s market competition, customers, and supply chain. As it turns out, that’s also good advice for small research-based firms trying to move from SBIR proof-of-concept funding to securing the larger Phase II awards.

With a $1 billion investment over the next three years, Advanced Research Projects Agency for Health (ARPA-H) will be a standalone agency within the National Institutes of Health (NIH) and is designed to produce quicker research outcomes.

The National Institutes of Health (NIH) announced last week that it is adopting modified criteria in its grant review process beginning on January 25, 2024. The new system will continue to focus on the scientific merit of proposals (i.e., importance, rigor, and feasibility), while de-emphasizing criteria that may introduce bias into the review.

NIH recently announced awards for five Research Evaluation and Commercialization Hubs (REACH) to accelerate the creation of small businesses and the transition of academic research discoveries into products that improve patient care and enhance health. These new REACH hubs will support innovators from diverse personal, educational, and professional backgrounds across 76 non-profit research institutions spanning 12 states.

The new hubs are: