Air Force and NIH Inventions Available for Licensing
AIR FORCE
Pursuant to the provisions of part 404 of title 37, Code of Federal Regulations, which implements Pub. L. 96-517, the Department of the Air Force announces the availability of certain Air Force owned inventions. The following list of patent applications and patents are available for Nonexclusive or Exclusive Licensing from the Air Force Research Laboratory (AFRL/DE or /VS) at Kirtland Air Force Base (AFB). Additional information concerning the inventions is available upon request.
All communications concerning this Notice should be sent to Mr. Kenneth Callahan, Patent Attorney, 377 ABW/JAN, 2251 Maxwell SE, Kirtland AFB, NM 87117. Mr. Callahan can be reached by telephone at (505) 846-1542, e-mail: Kenneth.Callahan@Kirtland.AF.MIL , or fax to (505) 846-0279.
Air Force Research Laboratory Patents Available for Licensing at Kirtland AFB, NM
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Title of invention
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Application:
09/563,469............................ Hermetically Sealed, High Energy Trigatron Switch.
09/562,873............................ Multifunctional Capillary System for Hoop Heat Pipe.
09/558,527............................ Circuit for Deriving the Position of a Fast Pulsing Laser.
09/558,456............................ Pneumatic Airborne Ejection System for Spacecraft Stages From Wide Body and Jet Transport Aircraft.
09/550,582............................ Smart Docking Surface for Space Serviceable Nano and Micro Satellites.
09/504,551............................ Space-based CW Laser Detector Package.
09/493,508............................ Birefringence Compensation Using a Single Nd:YAG Rod.
09/465,021............................ Liquid Spray Phase Change Cooling of Laser Devices.
09/444,984............................ Solar Sail for Power Generation in Space.
09/388,571............................ Space Environment Protection Satellite Door.
09/387,992............................ Molecular Field Programmable Gate Array.
09/384,901............................ Passive Vibroacoustic Attenuator for Structural Acoustic Control.
09/372,725............................ Broadband Grating Spectrometer Based on Dualband Focal Plane Array.
09/372,724............................ Adaptive Herschel-Quincke Tubes.
09/326,058............................ Composite ChamberCore Sandwich-type Structure with Inherent Acoustic Attenuation.
09/277,596............................ Ultra Wideband RF-enhanced Chemotherapy for Cancer Treatment.
09/277,595............................ Whole-spacecraft Hybrid (Active/Passive) Isolation System for Launch Vehicles.
09/277,593............................ Time Domain Focused High-power Microwave System for Cancer Treatment.
09/266,181............................ High-density Optical Interconnect with an Increased Tolerance of Misalignment.
09/252,379............................ Coupled Helmholtz Resonators for Broadband Acoustic Attenuation.--Allowed.
09/231,149............................ Active Edge Controlled Optical Quality Membrane Mirror. --Allowed.
09/178,876............................ Advanced Instrument Controller.
09/169,495............................ Post Process Metallization Interconnects for Microelectromechanical Systems (MEMS).
09/169,494............................ Post Process Deposition Shielding for Microelectromechanical Systems.--Allowed.
09/092,608............................ Liquid Crystal Active Optics Correction for Large Space-Based Optical Systems.-- Allowed.
6,061,034............................. Power Enhancer for Solid-state Switched Ultra Wideband Pulsers and array Transmitters.
6,047,541............................. HAN TEAN Mixing Gas Generator Propellant Tank Pressurizer for Launch Vehicles and Spacecraft.
6,040,935............................. Flexureless Multi-Stable Micromirrors for Optical Switching.
6,034,351............................. Cryogenic Pupil Stop for Dual-Band Infrared Focal Plane Array.
6,028,689............................. Multi-motion Micromirror.
6,020,724............................. Regulated Capacitor Charging Circuit Using a High Reactance Transformer.
6,005,305............................. Magnetic Voltage-Pulser.
5,944,913............................. High-Efficiency Multiple-Junction Solar Cells.
5,923,687............................. Bandwidth Enhancement and Broadband Noise Reduction in Injection-Locked Semiconductor Lasers.
5,900,986............................. Columnar Focal Lens.
5,835,545............................. Compact Intense Radiation System.
5,808,226............................. Grenade Shell Laser System.
5,774,490............................. Diode-Pumped Tm: YAG/HBr Four-Micron Laser System.
5,773,787............................. Plasma Gun Voltage Generator.
5,760,496............................. Inverse-Pinch Voltage Pulse Generator.
5,748,657............................. High Efficiency Constant Current Laser Drivers.
5,742,045............................. Apparatus Using Diode Laser Logic to Form a Configurable Optical Gate System.
5,734,303............................. Microwave Waveguide Mode Converter Having a Bevel Output End.
5,727,016............................. Spatially Coherent Diode Laser With Lenslike Media and Feedback From Straight-Toothed Gratings.
5,705,959............................. High Efficiency Low Distortion Amplification.
5,696,786............................. Solid-State Laser System.
5,694,602............................. Weighted System and Method for Spatial Allocation of a Parallel Load.
5,689,958............................. High Efficiency Thermal Electric Cooler Driver.
5,675,604............................. Portable Pumped Laser System.
5,658,488............................. Regeneration of BHP in a Plant Process.
5,656,873............................. Transmission Line Charging.
5,646,764............................. Optical Beam Scanner With Rotating Transmissive Optics.
5,629,802............................. Spatially Multiplexed Optical Signal Processor.
5,604,642............................. Laser Welding of Light-Weight Honeycomb Mirrors.
5,604,431............................. Integrated Grid Particle Impact Detector.
5,602,387............................. Method of Protecting an RF Receiver in a Hostile Electromagnetic Environment.
5,567,995............................. Multi-Winding Spiral Generator.
5,557,699............................. NLO Waveguide and Switch and Method.
5,553,629............................. Portable Medical Laser Pack System.
5,535,029............................. Spatial Light Modulator Having Amplitude Coupled With Binary Phase Mode.
5,504,578............................. Temporal Fringe Pattern Analysis System of a Laser Gain Media.
5,500,865............................. Phased Cascading of Multiple Nonlinear Optical Elements for Frequency Conversion.
5,458,043............................. Battery Charging Capacitors Electromagnetic Launcher.
5,457,685............................. Multi-Speaker Conferencing Over Narrowband Channels.
5,444,308............................. Nanosecond Transmission Line Charging Apparatus.
5,425,044............................. Compact, Burst Mode, Pulsed, High Energy, Blowdown Flow Photolytic Atomic Iodine Laser.
5,422,047............................. Carbonaceous Fuel Particles.
5,410,558............................. Variable Short Period Electron Beam Wiggler for Free Electron Lasers.
5,406,072............................. Method for Microbeam Ion Radiation Testing of Photonic Devices.SUMMARY: The inventions listed below are owned by agencies of the U.S. Government and are available for licensing in the U.S. in accordance with 35 U.S.C. 207 to achieve expeditious commercialization of results of federally-funded research and development. Foreign patent applications are filed on selected inventions to extend market coverage for companies and may also be available for licensing.
ADDRESSES: Licensing information and copies of the U.S. patent applications listed below may be obtained by contacting Marlene Shinn, J.D., at the Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, Maryland 20852-3804; telephone: 301/496-7056 ext. 285; fax: 301/402-0220; e-mail: ms482m@nih.gov A signed Confidential Disclosure Agreement will be required to receive copies of the patent applications.
Direct C-14 Oxidation of Opioids
Andrew Coop, Kenner C. Rice (NIDDK)
DHHS Reference No. E-032-99/1 filed 04 May 2000Opioid agonist drugs including the 14-hydroxy derivatives are utilized in the treatment of pain. The 14-hydroxy substituted opioid antagonists have also been found to be useful in the treatment of opiate abuse, opiate overdose and alcohol addiction. In addition, there are certain derivatives which have been found to be useful in the prevention of tolerance to morphine and as immunosuppressants. The 14-hydroxy agonist and antagonist drugs are produced by a multistep process from the starting material, thebaine, which is a minor constituent of opium and is generally in short supply. The demand for these products has resulted in a steadily increasing cost for thebaine and thebaine derivatives.
The present technology consists of a new and practical, nonchromatographic method of preparing 14-hydroxycodeinone by the direct oxidation of codeinone with cobalt (III) acetate (easily prepared in situ). The technology gives a 51% unoptimized yield of 14-hydroxycodeinone easily isolated by extractive workup and direct crystallization. This process is ultimately based on morphine (which is by far the major constituent and cheapest of the opium alkaloids) through the sequence: morphine to codeine to codeinone to 14-hydroxycodeinone. This technology is not limited by the availability of thebaine and thus offers more efficient production of the 14-hydroxy derivatives from opium.
Use of Oligonucleotides To Target Nucleic Acid Sequences Encoding Apolipoprotein B To Decrease Serum Apolipoprotein B and Cholesterol Levels
Thomas L Eggerman (FDA), Amy Patterson, Paul F. Torrence (NIDDK), Julie K Rhie
DHHS Reference No. E-236-98/0 filed 12 Oct 1999Coronary heart disease is caused by the atherosclerotic narrowing of the coronary arteries affecting nearly 14 million persons in the United States. Approximately 480,000 deaths in 1995 were caused by the disease and it is the leading cause of death in the United States today. Two of the established causes of atheroscleorosis include elevated cholesterol levels and elevations of the major protein responsible for carrying cholesterol--apolipoprotein B (apoB). Optimal therapy, however is still not available for the most severely affected patients, in particular those with familial hypercholesterolemia and those with elevated apoB levels.
The NIH announces a new gene therapy approach which will lower the risk for atheroscleoric heart disease by decreasing plasma cholesterol and apoB levels. Our researchers have shown that antisense DNA oligonucleotides targeted for apoB decreased apoB mRNA in a human liver cell line by up to 80%. This in turn has led to a new gene therapy which utilizes a vector designed to produce antisense mRNA targeted for apoB. The result is a decrease in liver apoB production, which is the major source of circulating apoB. These oligonucleotides and oligonucleotide analogs are a novel and useful way of reducing low density lipoprotein (LDL) in patients, as well as for research and diagnostic purposes.
T20/D178 and T21/D107 Are Activators of Human Phagocyte Formyl Peptide ReceptorsJi Ming Wang (NCI), Joost J Oppenheim (NCI), Shao-Bo Su, Wang-Hua Gong,
Philip M. Murphy (NIAID), Ji-Liang Gao (NIAID)
DHHS Reference No. E-164-99/0 filed 05 May 1999The use of immunotherapy to treat inflammatory diseases is prescribed to thousands each and every year. In use currently are steroidal and non-steroidal anti-inflammatory drugs, which have serious side effects including: adrenal suppression, gastrointestinal disorders, increased susceptibility to infections, fluid retention and bone loss.
The NIH announces a new technology which can be used in drug discovery dealing with the modulation of the immune response. This technology identifies two polypeptides, T20/DP178 and T21/DP107, which are peptide domains of the HIV-1 envelope protein and are potent chemoattractants and activators of human peripheral blood phagocytes (monocytes and neutrophils) but not T lymphocytes. These polypeptides have been determined to interact with the Formyl Peptide Receptors (FPR), which in turn up-regulates the immune response by inducing cell migration and calcium mobilization. The activation of FPR class receptors by their agonists also results in desensitization of cell responses to other chemotactic factors. By identifying analogs to T20/DP178 and T21/DP107 and then evaluating their ability to bind to the FPR, one will be able to determine if the analog is a good candidate for either inhibiting or activating the immune response.
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